We advise a brand new highly integrated field-programm-able gate array (FPGA) only signal digitization way of individual signal digitization of your time-of-flight positron emission tomography (TOF PET). We configured I/O port from the FPGA having a single-ended memory interface (SeMI) input receiver. The SeMI is really a single-ended current-referenced interface which has a common reference current per I/O Bank, so that each SeMI input receiver may serve as a current comparator. The FPGA-only digitizer that utilizes the only-ended input receivers doesn’t need another digitizing integrated nick, and may obtain two times as numerous signals as that using LVDS input receivers. We implemented a very integrated digitizer composed of 82 energy and 82 timing channels utilizing a 28-nm FPGA. The power and arrival time were measured utilizing a 625-ps binary counter, along with a 10-ps time-to-digital ripper tools (TDC), correspondingly. We first measured the intrinsic characteristics from the suggested FPGA-only digitizer. The SeMI input receiver functioned because the current comparator without undesirable offset current. The conventional deviation value of times difference measured using two SeMI input receivers with particular TDCs was under 14.6 ps RMS. Additionally, we given signals in the TOF PET detectors towards the SeMI input receivers directly and picked up data. The TOF PET detector contained a 3 × 3 × 20 mm3 LYSO very along with a plastic photomultiplier. The power resolutions were 7.7% and seven.1% for 2 TOF PET detectors. The coincidence resolving there was a time 204 ps full width at half maximum. The SeMI digitizer having a high-performance signal digitizer, processor, and-speed transceivers supplies a compact all-in-one data acquisition system.