Model AMPAR transport inside a unipolar neuron
Heteromeric and homomeric Glutamate Receptors (GLR-1 and GLR-1/2) are transported through the molecular motor complex Kinesin-1. Neuronal activity, Calcium and CaMKII regulate transport in the cell body in addition to delivery and removal at synapses. The Hoerndli lab research aims to know how this is done and just what pathways regulate this method during memory establishment and cellular ageing.
Hoerndli F.J., A. Kallarackal, along with a.V. Maricq (2015) Mobile AMPARs are needed for synaptic plasticity. Channels(Austin) 9:230-2.
Hoerndli F.J., R. Wang, J.E. Mellem, A. Kallarackal, P.J. Brockie, C. Thacker, D.M. Madsen along with a.V. Maricq (2015) Neuronal activity and CaMKII regulate kinesin-mediated transport of synaptic AMPARs. Neuron 86: 1-18. (Reported in Faculty 1000)
Hoerndli F.J.*, D.A. Maxfield*, P.J. Brockie, J.E. Mellem, E. Jensen, R. Wang, D.M. Madsen along with a.V. Maricq (2013) Kinesin-1 regulates synaptic strength by mediating the delivery, removal and redistribution of AMPA receptors. Neuron 80:1421-37. Feature article (*, co-first authors) (Reported in Faculty 1000)
Brockie, P.J., M. Jensen, J. Mellem, E. Manley, R. Wang, D.A. Maxfield, F.J. Hoerndli, D.M. Madsen along with a.V. Maricq (2013) Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron 80:129-42.
Wang, R., J.E. Mellem, M. Jensen, P.J. Brockie, C.S. Master, F.J. Hoerndli, D.M. Madsen along with a.V. Maricq (2012) The SOL-2/Neto auxiliary protein modulates the part of AMPA-subtype ionotropic glutamate receptors. Neuron 75:838-50.
Jensen, M., F.J. Hoerndli, P.J. Brockie, R. Wang, E. Manley, D. Maxfield, M.M. Francis, D.M. Madsen along with a.V. Maricq (2012) Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity within the adult central nervous system. Cell 149:173-87.
Stetak, A., F. Hörndli, A.V. Maricq, S. van living room Heuvel along with a. Hajnal (2009) Neuron-specific regulating associative learning and memory by MAGI-one in C. elegans. PLoS One 4:e6019.
Hoerndli, F.J., M. Walser, E. Fröhli Hoier, D. de Quervain, A. Papassotiropoulos along with a. Hajnal (2009) A conserved purpose of C. elegans CASY-1 calsyntenin in associative learning. PLoS One 4:e4880.
Hoerndli, F.J., S. Pelech, A. Papassotiropoulos and J. Götz (2007) Abeta treatment and P301L tau expression within an Alzheimer’s tissue culture model act synergistically to advertise aberrant cell cycle re-entry. Eur J Neurosci 26:60-72.
Huentelman, M.J., A. Papassotiropoulos, D.W. Craig, F.J. Hoerndli, J.V. Pearson, K.D. Huynh, J. Corneveaux, J. Hänggi, C.R. Modardori, A. Buchmann, E.M. Reiman, K. Henke, D.J. de Quervain and D.A. Stephan (2007) Calmodulin-binding transcription activator 1 (CAMTA1) alleles predispose human episodic memory performance. Mol Genet 16:1469-77.
Papassotiropoulos, A., D.A. Stephan, M.J. Huentelman, F.J. Hoerndli, D.W. Craig, J.V. Pearson, K.D. Huynh, F. Brunner, J. Corneveaux, D. Osborne, M.A. Wollmer, A. Aerni, D. Coluccia, J. Hänggi, C.R. Mondadori, A. Buchmann, E.M. Reiman, R.J. Caselli, K. Henke and D.J. de Quervain (2006) Common Kibra alleles are connected with human memory performance. Science 314:475-78.
Hoerndli, F.J., M. Toigo, A. Schild and J. Götz (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase squence of events. Rectal Biochem 335:30-41.
Chen, F., M.A. Wollmer, F. Hoerndli, G. Münch, B. Kuhla, E.I. Rogaev, M. Tsolaki, A. Papassotiropoulos and J. Götz (2004) Role for glyoxalase I in Alzheimer’s. Proc Natl Acad Sci USA 101:7687-92.
Ferrari, A., F. Hoerndli, T. Baechi, R.M. Nitsch and J Götz (2003) beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. J Biol Chem 278:40162-68.
Streffer, J.R., A. Papassotiropoulos, P. Kurosinski, A. Signorell, M.A. Wollmer, M. Tsolaki, V. Iakovidou, F. Hörndli, J. Bosset, J. Götz, R.M. Nitsch and C. Hock (2003) Saitohin gene isn’t connected with Alzheimer’s. J Neurol Neurosurg Psychiatry 74:362-63.
Götz, J., D. David, F. Hoerndli, Y.D. Ke, N. Schonrock, A. Wiesner, T. Fath, L. Bokhari, Y.A. Lim, N. Deters and L.M. Ittner (2008) Functional genomics dissects pathomechanisms in tauopathies: mitosis failure and unfolded protein response. Neurodegener Dis 179-81.
Hoerndli, F., D.C. David and J. Götz (2005) Functional genomics meets neurodegenerative disorders. Part II: Application and knowledge integration. Prog Neurobiol 76:169-88.
David, D.C., F. Hoerndli and J. Götz (2005) Functional genomics meets neurodegenerative disorders. Part I: Transcriptomic and proteomic technology. Prog Neurobiol 76:153-68.
Götz, J., J.R. Streffer, D. David, A. Schild, F. Hoerndli, L. Pennanen, P. Kurosinski and F. Chen (2004) Transgenic animal types of Alzheimer’s and related disorders: histopathology, behavior and therapy. Mol Psychiatry 9:664-83.
Götz, J., A. Schild, F. Hoerndli and L. Pennanen (2004) Amyloid-caused neurofibrillary tangle formation in Alzheimer’s: insight from transgenic mouse and tissue-culture models. Int J Dev Neurosci 22:453-65.